Orthopaedic Research Newsletter

June 2024

Michigan Integrative Musculoskeletal Health Core Center (MiMHC) Eighth Annual Symposium

The Eighth Annual Musculoskeletal Health Symposium was held Thursday, May 16, 2024, at the Kahn Auditorium and Atrium at the Biomedical Science Research Building in Ann Arbor, MI. Over one hundred and fifty people attended the event in person along with virtual participants. The event saw 48 abstract poster submissions and 10 posters were from our department. Our keynote speaker was Dr. Teresa Zimmers who spoke about “Mechanisms of muscle loss in physiological and pathological cachexia”.

For further information about the event: https://mimhc.med.umich.edu

Congratulations Faculty!

Congratulations to our faculty who have received promotions effective September 1. Your hard work, dedication, and commitment to excellence have been recognized, and this achievement is well-deserved.

Dr. Adam Abraham, PhD

Promotion to

Assistant Professor

Dr. Megan Killian, PhD

Promotion to

Associate Professor

Dr. Tristan Maerz, PhD

Promotion to

Associate Professor

Congratulations!

Adam C. Abraham, Ph.D.

Research Investigator of Orthopaedic Surgery

Congratulations, Dr. Adam Abraham!

R01 Award

Title: "Extracellular Matrix Regulation of Inflammatory Signaling in Tendon"

Funding: $1,750,000

Duration: 5 years

The work proposed in this award aims to engineer a novel tendon-specific microphysiological system to understand how the loss of extracellular matrix stiffness increases inflammatory signaling in tendinopathy. Knowledge gained from these studies will inform the development of therapeutic targets to treat tendon disease. Our scientific partners are Dr. Brendon Baker in Biomedical Engineering and Dr. Claudia Loebel in Materials Science & Engineering. Dr. Paul Talusan and the Foot and Ankle service continue to be critical supporters of our work by providing patient-derived tissue samples across a spectrum of tendinopathies.

Congratulations, Emma Snyder-White!

Research Staff Award

Emma works in the Orthopaedic Surgery Research Service (OSRS) Histology Core managing the paraffin and cryosectioning portions of our services. She performs a wide variety of histology services for research labs in the department, across campus, and even outside of the university. Emma consults on new project ideas or with labs and individuals who are using histology in their work for the first time. She also provides training to students and researchers who would like to use our rental equipment to perform their histology. She assists Carol with the plastic side as well and generally helps to manage the core.

Congratulations, Dr. Alex Knights!

John Haddad Young Investigator Award from ASBMR/AIMM

Achieving the John Haddad Young Investigator Award allowed Dr. Knights to attend the Advances in Mineral Metabolism (AIMM) conference in Snowmass, CO on April 8th-12th, 2024. He presented his work on osteophyte formation. Congratulations to Dr. Knights!

Evan Buettmann (left) and Alex Knights (right) at the AIMM conference.

Congratulations, Christina Capobianco!

MICHR T32 Predoctoral Award

Christina was awarded the Michigan Institute of Clinical and Health Research (MICHR) Predoctoral T32 Training Program in May 2023. This is a 2-year program focused on advancing translational science and fostering the growth of trainees as translational scientists. This program encompasses didactic and seminar courses, networking opportunities, as well as research support. She is supported by this grant for her research focused on improving ischemic fracture healing through therapeutic intervention. Congratulation Christina!

UROP AWARDS

Congratulations, Allison Risha!

Blue Ribbon Certificate

Allison's Project: Due to their cellular morphology, tendons are unable to be seen in 3D via microCT imaging. This prevents us from a deeper study of tendons after injury and makes it difficult to compare tendon shape after a change in genotype. Past research shows that eosin was found to be an effective contrast enhancing agent to help improve the visibility of previously radiopaque structures when scanned via MicroCT. Allison's project consisted of creating a protocol to stain tendons in an eosin based dye and scan them in the MicroCT with the goal of improving 3D visibility of the tendon, specifically focused on being able to visualize the tendon at the cellular level. After staining, we were able to clearly see the tendon in 3D. Although the cells of the tendon were a bit too small to be seen, the ability to see the overall shape and size of the tendon will greatly enhance our study of the structure.

The UROP symposium celebrates the partnerships created between students and research mentors and serves as a conference where students present their research projects and learn about the research their fellow UROP students have worked on throughout the program. Congratulations to Allison on achieving this award and kudos to Nicole on her mentorship!

Nicole Migotsky (left) and Allison Risha (right) at the UROP Symposium.

Congratulations, Zaynah Saraya!

Two Blue Ribbon Certificates!

Zaynah's Project: Approximately 15 million fractures occur yearly in the United States, however around 10% of these fractures will result in a nonunion or malunion, meaning that they will not heal without surgical intervention. Many factors can contribute to impaired fracture healing including age, ischemia, smoking, chronic inflammation, infection, and polytrauma injuries. This presents a pressing need to understand the mechanisms that underlie impaired healing and understand the processes that facilitate fracture healing under healthy and impaired conditions. Our studies specifically focus on modulating gene expression and understanding how this impacts fracture callus formation and mineralization. Within the lab we have shown that global deletion of the gene thrombospondin 1 (TSP1) leads to impaired fracture callus formation and healing, however the exact mechanisms are not well defined. TSP1 has been shown to have roles involved in regulation of blood vessel growth, inflation, and fibrosis. Our study seeks to assess how different cell populations expression of TSP1 leads to this impaired healing. Our lab has shown that TSP1 is highly expressed by the immune population during fracture callus formation. Thus, we hypothesize that inhibition of TSP1 in the immune population will have the same effect of impaired healing as a global deletion. We can assess this through analysis of cartilage and bone formation using Safranin-O/Fast green staining. Through immunofluorescent staining we can also interrogate differences in blood vessel growth.

Research Highlight

Yadav Wagley,

Research Investigator of Orthopaedic Surgery

Yadav Wagley

Research Investigator, Orthopaedic Surgery

Yadav Wagley, PhD, has been with the department since 2017. Dr. Wagley is an active member of the American Society for Bone and Mineral Research (ASBMR) and Orthopaedic Research Society (ORS), which are his primary academic communities.

Research Interest:

Dr. Wagley is an Early-Stage Investigator with a passion for uncovering signaling crosstalk and functional role of novel genes during mesenchymal stem/progenitor cell (MSC) differentiation into osteoblasts, chondrocytes, and adipocytes. He has been at the Orthopaedic Research Laboratories (ORL) since 2017 under the direct supervision of Dr. Kurt D. Hankenson. Working alongside Dr. Hankenson, he has successfully developed and characterized various in vitro and in vivo research models for mechanistic and translational interventions for enhanced bone regeneration. Dr. Wagley’s future research program focuses on functionalizing novel bone mass effector genes regulated by non-coding genomic variants. He collaborates with geneticists and bio-informaticists from Children’s Hospital of Philadelphia to utilize assay for transposase-accessible chromatin, capture-C, and cutting-edge genome editing technologies to intersect bone mineral density (BMD) genome-wide association study (GWAS) data in differentiating human osteoblasts to implicate novel BMD effector genes. The functional requirement of putative genes is established using gene silencing experiments in differentiating hMSC and human fetal osteoblasts. An additional goal of his research is to understand the genetic regulatory mechanism of these novel effector genes during progenitor cell differentiation and understand the overall molecular changes elicited in their absence both in vitro and in vivo. The ultimate goal of his research program is to advocate the therapeutic targeting of these genes for bone and cartilage regeneration through collaboration with other principal investigators within the ORL.

Examples of some of Dr. Wagley’s active research projects include:

1. EPDR1 specification of bone turnover by inflammatory crosstalk within the bone microenvironment

2. Osteochondral fate specification of mesenchymal progenitor cells by microRNA-199a-5p modulation

3. Elucidating the integration of bone morphogenetic protein and Notch signaling pathway for enhanced human osteoblast differentiation

Welcome New Orthopaedic Research Staff!

Allison Jordan

Clinical Research Coordinator

Allison will primarily support our trauma/spine services. Allison received her bachelor’s degree from the University of Michigan and has a master’s degree from Middlebury College in addition to a Master of Social Work degree from Western Michigan University. Prior to joining our team, she was working in the Department of Neurology as a CRC and has several years of clinical research experience throughout various departments here at UM. In her spare time, Allison enjoys talking with friends, watching movies and TV shows, and playing with her cat.

Killian-Abraham Labs Relocation

The Killian and Abraham Labs have officially relocated to the North Campus Research Complex (NCRC), Building 20. This state-of-the-art facility provides an innovative environment that fosters collaboration and cutting-edge research. The NCRC facilities also offer resources designed to support the needs of faculty, staff, and trainees.

This move was facilitated by the workplace services team of Michigan Medicine including Adam Freeland, Brandon Wunderley, and John Konyha.

Special kudos to Research Service members Melissa Li, Nicole Migotsky, Rob Goulet, and Conor Locke for facilitating the move process as well as the Jepsen Lab and Histology Core for the warm welcome to NCRC.

Nth Dimensions Internship Scholar

Renee Megwa

Renee Megwa, a student from Sam Houston State University College of Osteopathic Medicine, is visiting our department this summer. As a DO student at Sam Houston State University, TX, Renee is enthusiastic about learning within our department. We invite you to consider hosting Renee, providing opportunities to benefit from your research experience in your lab, engage in meetings with faculty and trainees, shadow experiments, and potentially participate in hands-on activities. If you are interested, please contact Dr. Megan Killian (mlkillia@med.umich.edu) or Sarah Boston (sjayers@med.umich.edu) for further details.

Diversity, Equity, & Inclusion

Youth Summit at the Big House

May 18, 2024

A HUGE Thank-You to our wonderful volunteers who helped at the Youth Summit!

Christina Capobianco

Davin Gong

Torsten Grabbert

Lindsey Lammlin

Megan Killian

Nik Patel

Eileen Crawford

We appreciate you taking the time and making the effort to bring the world of Orthopaedic to underserved student populations!

Staff Appreciation Celebration!

From left: Carlisle DeJulius, Miranda Cosman, Alexander Knights, Amit Chougule

Staff Appreciation Event!

On May 24, the Department of Orthopaedic Surgery hosted a staff appreciation event to honor and acknowledge our dedicated team. We extend our gratitude for your exceptional efforts throughout this year. Thank you to our orthopaedic research team!

Research Resource Spotlight

Tissue Biomechanics Shadowing:

Trainees are welcome to shadow Research Engineer, Conor Locke, for p30 testing of murine mineralized tissue. This can also include educational discussion of biomechanical testing theory, decision-making for testing protocols, assumptions of tests, and data interpretation/analysis. Reach out to cslocke@umich.edu for availability.

Recent Publications

Aibinder, W.R. “Being a Good Mentor & Mentee,” April 19, 2024.
Johnson, A., P.C. Blome, E. Candas, F. Dumas, C. Erfurt-Berge, and A. Garten. “Implementing the Wound Balance Concept into Routine Practice Worldwide.” Edited by T. Kopal, M. Marques, Z. Moore, H. KR Nair, J. Schaefer, H. Smola, and S. Trouth. Wounds International 15, no. 02 (April 24, 2024).
Gohel, N., P. Khambete, L. Gerhardinger, A.N. Miller, P. Wolinsky, M. Jarman, J.W. Scott, R. Vaidya, M.R. Hemmila, and B.W. Oliphant. “Characterizing Trauma Patients with Delays in Orthopaedic Process Measures.” J Trauma Acute Care Surg, April 30, 2024. https://doi.org/10.1097/TA.0000000000004346.
Sangji, N., J. Dougherty, C. Tignanelli, H. Maqsood, A. Cain-Nielsen, B. Oliphant, and M. Hemmila. “Calculation and Feedback of Risk-Adjusted Antibiotic Days as a Process Measure in a Statewide Trauma Collaborative.” American Surgeon, April 30, 2024.
Adidharma, W., and K.C. Chung. “Recent Advances in Upper Extremity Microsurgery: From Traditional to Perforator Flaps.” Hand Clinics 40, no. 2 (May 1, 2024): 161–66. https://doi.org/10.1016/j.hcl.2023.08.006.
Baxter, N.B., C.H. Lin, B.I. Wallace, J.S. Chen, C.F. Kuo, and K.C. Chung. “Development of a Machine Learning Model to Predict the Use of Surgery in Patients With Rheumatoid Arthritis.” Arthritis Care and Research 76, no. 5 (May 1, 2024): 636–43. https://doi.org/10.1002/acr.25287.
Billig, J.I., S.V. Kotsis, L. Kong, L. Wang, K.C. Chung, J. Adkinson, J. Fowler, et al. “Predictors and Variation in Steroid Injection Use for Carpal Tunnel Syndrome from a Multicenter Quality Collaborative.” Plastic and Reconstructive Surgery 153, no. 5 (May 1, 2024): 1075–82. https://doi.org/10.1097/PRS.0000000000010899.
Chim, H., and K.C. Chung. “Innovations in Microsurgical Reconstruction in the Upper Extremity.” Hand Clinics 40, no. 2 (May 1, 2024): xiii. https://doi.org/10.1016/j.hcl.2024.02.001.
Garcia, S.A., A.K. Johnson, M. Orzame, and R.M. Palmieri-Smith. “Biomechanical Effects of Manipulating Preferred Cadence During Treadmill Walking in Patients With ACL Reconstruction.” Sports Health 16, no. 3 (May 1, 2024): 420–28. https://doi.org/10.1177/19417381231163181.
Huddleston, H.P., J.S. Kurtzman, L. Deegan, W. Hayes, K. Austin, J. Carter, W.R. Aibinder, and S.M. Koehler. “Negative Ulnar Variance Lessens DRUJ Instability After DRUJ Disruption: A Biomechanical Analysis.” Hand 19, no. 3 (May 1, 2024): 448–55. https://doi.org/10.1177/15589447221124233.
Chua, K-P., T.D. Nguyen, C.M. Brummett, A.S. Bohnert, V. Gunaseelan, M.J. Englesbe, S. Lee, and J.F. Waljee. “Association Between Prescription Drug Monitoring Program Use Mandate and Opioid Prescribing and Patient-Reported Outcomes After Surgery.” Ann Surg, May 8, 2024. https://doi.org/10.1097/SLA.0000000000006332.
Jacobson, A.R., J. Blaszczak, J. Ahn, and B.L. Viglianti. “DEXA Screening for Transgender and Gender Diverse Patients: An Overview of Current Guidance and Call for Improved Protocols.” Academic Radiology 31, no. 5 (May 1, 2024): 2159–63. https://doi.org/10.1016/j.acra.2023.10.037.
Klosterman, E.L., A.J. Tagliero, T.R. Lenters, P.J. Denard, E. Lederman, R. Gobezie, B. Sears, et al. “The Subcoracoid Distance Is Correlated with Pain and Internal Rotation after Reverse Shoulder Arthroplasty.” JSES International 8, no. 3 (May 1, 2024): 528–34. https://doi.org/10.1016/j.jseint.2024.01.010.
Klueh, M.P., L.M. Swany, J.P. Troost, and E. Crawford. “Return to Sports Rates in Pediatric Patients After Bilateral Versus Unilateral Medial Patellofemoral Ligament Reconstruction.” American Journal of Sports Medicine, May 1, 2024.
Klueh, M.P., L.M. Swany, J.P. Troost, and E.A. Crawford. “Return to Sports Rates in Pediatric Patients After Bilateral Versus Unilateral Medial Patellofemoral Ligament Reconstruction.” American Journal of Sports Medicine 52, no. 6 (May 1, 2024): 1527–34. https://doi.org/10.1177/03635465241240154.
Kim, Y.J., and K.C. Chung. “Failure: A Close Relative.” Plastic and Reconstructive Surgery 153, no. 5 (May 1, 2024): 985–88. https://doi.org/10.1097/PRS.0000000000011216.
Miller, A.K., P. Zakko, D.K. Park, V.W. Chang, L. Schultz, K. Springer, T.M. Hamilton, et al. “Cervical Disc Arthroplasty versus Anterior Cervical Discectomy and Fusion: An Analysis of the Michigan Spine Surgery Improvement Collaborative Database.” Spine Journal 24, no. 5 (May 1, 2024): 791–99. https://doi.org/10.1016/j.spinee.2023.12.004.
Pak, T., M.E. Menendez, R. Gobezie, B.W. Sears, E. Lederman, A. Romeo, A. Shah, et al. “Rates of Subacromial Notching Are Low Following Reverse Shoulder Arthroplasty with a 135° Inlay Humeral Component and a Lateralized Glenoid.” JSES International 8, no. 3 (May 1, 2024): 522–27. https://doi.org/10.1016/j.jseint.2024.01.009.
Patel, V., J.J. Wind, I. Aleem, T. Lansford, M.A. Weinstein, A. Vokshoor, P.G. Campbell, et al. “Adjunctive Use of Bone Growth Stimulation Increases Cervical Spine Fusion Rates in Patients at Risk for Pseudarthrosis.” Clinical Spine Surgery 37, no. 4 (May 1, 2024): 124–30. https://doi.org/10.1097/BSD.0000000000001615.
Simha, S., Y. Ahmed, C.M. Brummett, J.F. Waljee, M.J. Englesbe, and M.C. Bicket. “Impact of the COVID-19 Pandemic on Opioid Overdose and Other Adverse Events in the USA and Canada: A Systematic Review.” Regional Anesthesia and Pain Medicine 49, no. 5 (May 1, 2024): 361–62. https://doi.org/10.1136/rapm-2022-104169.
Susarla, S.M., J.B. Friedrich, and K.C. Chung. “The ‘Loss Years’ of Residency Education: Overcoming COVID-19 Learning Gaps among Trainees.” Plastic and Reconstructive Surgery 153, no. 5 (May 1, 2024): 1199–1201. https://doi.org/10.1097/PRS.0000000000011220.
Rodriguez, A., O. Kripfgans, Ph.D. Kozloff K.M., A. Samal, M. Shehabeldin, and H-L. Chan. “Ultrasound-Based Jawbone Surface Quality Evaluation after Alveolar Ridge Preservation.” Journal of Periodontology, May 14, 2024.
Crawford, E. “Healthcare Disparities In The Young, Athletic Population,” May 16, 2024.
Beaulé, P.E., J.C.F. Verhaegen, J. Clohisy, I. Zaltz, M. Stover, E. Belzile, E. Sink, et al. “The Otto Aufranc Award: Does Hip Arthroscopy at the Time of Periacetabular Osteotomy Improve the Clinical Outcome for the Treatment of Hip Dysplasia? A Multi-Center Randomized Clinical Trial.” J Arthroplasty, May 18, 2024. https://doi.org/10.1016/j.arth.2024.05.035.
Novak, S., H. Tanigawa, V. Singh, S.H. Root, T.A. Schmidt, K.D. Hankenson, and I. Kalajzic. “Endothelial to Mesenchymal Notch Signaling Regulates Skeletal Repair.” JCI Insight, May 23, 2024. https://doi.org/10.1172/jci.insight.181073.
Hones, K.M., R.J. Cueto, L.C. Ndjonko, B.T. Raymond, T.R. Buchanan, W.R. Aibinder, R.C. Srinivasan, T.W. Wright, J.J. King, and K.A. Hao. “Establishing the Diagnosis of Radial Tunnel Syndrome: A Systematic Review of Published Clinical Series.” Eur J Orthop Surg Traumatol, May 24, 2024. https://doi.org/10.1007/s00590-024-04003-8.
Herzberg, S.D., G.A. Garriga, N.B. Jain, and A. Giri. “Elevated Body Mass Index Is Associated with Rotator Cuff Disease: A Systematic Review and Meta-Analysis.” Arthroscopy Sports Medicine and Rehabilitation, May 2024, 100953. https://doi.org/10.1016/j.asmr.2024.100953.
McHugh, M., S. Muscatelli, M. Squires, N. Honey, C. Locke, and E. Dailey. “Aspirin Is Not for Everyone: Discharge to Non-Home Facilities After Total Hip and Knee Arthroplasty Increases Risk of Venous Thromboembolism.” In Arthroplast Today, 27:101368. United States, 2024. https://doi.org/10.1016/j.artd.2024.101368.
Okanlami, O.O., J.M. Kreschmer, S. Gupta, A. Lee, A.V. Sarma, and C.S. Streur. “MP21-10 ‘I’M A BATHROOM EXPERT’: BALANCING COLLEGE LIFE AND BLADDER AND BOWEL PROGRAMS FOR STUDENTS WITH PHYSICAL DISABILITIES.” Journal of Urology 211, no. 5S (May 2024): e333. https://doi.org/10.1097/01.ju.0001008844.84871.17.10.
Prado, I.P., E.T. Hurley, R.M. Danilkowicz, A. Bedi, A. Golant, J.A. Grant, A.J. Hughes, et al. “Clinical and Research Follow-Up for Knee Cartilage Injuries – An International Consensus Statement.” Journal of Cartilage & Joint Preservation, May 2024, 100192. https://doi.org/10.1016/j.jcjp.2024.100192.
Arnold, N.D., A.J. Chrzan, K. Chan, and T.R. Bush. “The Female Thumb Carpometacarpal Joint: Motion and Force Changes Due to Arthritis and Surgical Intervention.” J Biomech Eng 146, no. 6 (June 1, 2024). https://doi.org/10.1115/1.4064551.
Deshpande, N., M. Hadi, T.R. Mansour, E. Telemi, T. Hamilton, J. Hu, L. Schultz, et al. “The Impact of Anxiety and Depression on Lumbar Spine Surgical Outcomes: A Michigan Spine Surgery Improvement Collaborative Study.” Journal of Neurosurgery. Spine 40, no. 6 (June 1, 2024): 741–50. https://doi.org/10.3171/2023.12.SPINE23860.
Goetti, P., W.R. Aibinder, N.R. Rollick, D.M. Rouleau, and K.J. Faber. “Corrective Open-Wedge Valgus Proximal Humerus Lengthening Osteotomy. Technique and Case Series.” Techniques in Hand & Upper Extremity Surgery 28, no. 2 (June 1, 2024): 74–79. https://doi.org/10.1097/BTH.0000000000000466.
Harrison, K., D.S.B. Williams, B.J. Darter, R.F. Zernicke, M. Shall, and S. Finucane. “Effect of Strength and Plyometric Training on Kinematics in Female Novice Runners.” Journal of Strength and Conditioning Research 38, no. 6 (June 1, 2024): 1048–55. https://doi.org/10.1519/JSC.0000000000004757.
Kahlenberg, C.A., M.M. Kheir, I.K. Selkridge, F.J. Quevedo Gonzalez, Y.F. Chiu, T.M. Wright, B.P. Chalmers, and P.K. Sculco. “Clinical and Biomechanical Evaluation of Mid-Level Constrained and Posterior-Stabilized Polyethylene Inserts in Primary Total Knee Arthroplasty: An Analysis of 12,674 Cases.” Journal of Arthroplasty 39, no. 6 (June 1, 2024): 1518–23. https://doi.org/10.1016/j.arth.2023.12.018.
Leopold, S.S., R.N. Hensinger, A.J. Schoenfeld, M. Swiontkowski, M.J. Rossi, and K.J. Templeton. “Improving How Orthopedic Journals Report Research Outcomes Based on Sex and Gender.” JOR Spine 7, no. 2 (June 1, 2024). https://doi.org/10.1002/jsp2.1334.
Nasr, A.J., A. Kowalske, J. Wang, N.B. Jain, and M. Khazzam. “Predicting Pain and Function with the Neutrophil-to-Lymphocyte Ratio in Patients Following Primary Reverse Total Shoulder Arthroplasty.” Seminars in Arthroplasty JSES 34, no. 2 (June 1, 2024): 332–39. https://doi.org/10.1053/j.sart.2023.12.005.
Ogunsola, O., J.R. Linzey, M.M. Zaki, V. Chang, L.R. Schultz, K. Springer, M. Abdulhak, et al. “Risk Factors of Emergency Department Visits Following Elective Cervical and Lumbar Surgical Procedures: A Multi-Institution Analysis from the Michigan Spine Surgery Improvement Collaborative.” Journal of Neurosurgery. Spine 40, no. 6 (June 1, 2024): 751–57. https://doi.org/10.3171/2024.1.SPINE23842.
Pak, T., J. Ardebol, M.E. Menendez, R. Gobezie, B.W. Sears, E. Lederman, A. Shah, et al. “Robert H. Cofield, MD, Award for Best Oral Presentation 2023: Up to 8 Mm of Glenoid-Sided Lateralization Does Not Increase the Risk of Acromial or Scapular Spine Stress Fracture Following Reverse Shoulder Arthroplasty with a 135° Inlay Humeral Component.” Journal of Shoulder and Elbow Surgery 33, no. 6 (June 1, 2024): S1–8. https://doi.org/10.1016/j.jse.2023.11.018.
Pierson, C.J., N. Velez, N.B. Jain, and C. Konda. “Changing Stimulation Frequency Improves Implanted Peripheral Nerve Stimulator Effects after Posttraumatic Total Hip Arthroplasty: A Case Report.” American Journal of Physical Medicine and Rehabilitation 103, no. 6 (June 1, 2024): E67–70. https://doi.org/10.1097/PHM.0000000000002411.
Yoon, A.P., H. Wu, W.T. Chung, L. Wang, and K.C. Chung. “Comparison of Long-Term Healthcare Cost and Utilisation of Nonoperative and Surgical Management of Thumb CMC Arthritis.” Journal of Hand Surgery Asian-Pacific Volume 29, no. 3 (June 1, 2024): 191–99. https://doi.org/10.1142/S2424835524500206.
Mesko, J.W., H. Zheng, R.E. Hughes, and B.R. Hallstrom. “Individualized Surgeon Reports in a Statewide Registry.” J Bone Joint Surg Am, June 4, 2024. https://doi.org/10.2106/JBJS.23.01297.
Burt, K.G., M.K.M. Kim, D.C. Viola, A.C. Abraham, and N.O. Chahine. “Nuclear Factor κB Overactivation in the Intervertebral Disc Leads to Macrophage Recruitment and Severe Disc Degeneration.” Sci Adv 10, no. 23 (June 7, 2024): eadj3194. https://doi.org/10.1126/sciadv.adj3194.
Wang, Z.R., E. Guo, C.N. Carender, B.R. Hallstrom, and M.M. Kheir. “Preoperative HOSS and KOOS Independently Predict Achievement of Post-Operative Minimal Clinically Important Differences (MCID) but Not Patient-Reported Satisfaction.,” June 7, 2024.
Garcia, S.A., M. White, and R. Palmieri-Smith. “LB-021 ASSOCIATIONS BETWEEN SAGITTAL PLANE KNEE COMPLEXITY AND EXERCISE-INDUCED CHANGES IN CARTILAGE THICKNESS AND ECHO INTENSITY IN INDIVIDUALS WITH ACL-RECONSTRUCTION.” Osteoarthritis and Cartilage 32, no. 6 (June 2024): 762–63. https://doi.org/10.1016/j.joca.2024.03.023.
Mitchell, R.J., S. Wijekulasuriya, A. Mayor, F.K. Borges, A.C. Tonelli, J. Ahn, H. Seymour, and Fragility Fracture Network Hip Fracture Audit Special Interest Group. “Principles for Management of Hip Fracture for Older Adults Taking Direct Oral Anticoagulants: An International Consensus Statement.” Anaesthesia 79, no. 6 (June 2024): 627–37. https://doi.org/10.1111/anae.16226.
Brandon W. Henry, Cynthia Dela Cruz, Robert W. Goulet, Bonnie T. Nolan, Conor Locke, Vasantha Padmanabhan, Molly B. Moravek, Ariella Shikanov, View ORCID Profile Megan L. Killian (2024). Bone quality following peripubertal growth in a mouse model of transmasculine gender-affirming hormone therapy [Pre-print, bioRxiv]

Upcoming Funding Opportunities and Deadlines

NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed): PA-20-185
NIH Research Project Grant (Parent R01 Basic Experimental Studies with Humans Required): PA-20-184
NIH Research Project Grant (Parent R01 Clinical Trial Required): PA-20-183
NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Not Allowed): PA-20-195
NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Required): PA-20-194
NIH Exploratory/Developmental Research Grant Program (Parent R21 Basic Experimental Studies with Humans Required): PA-20-196

Jump Back Up July

There are many ways to jump back up throughout your day. One could go outside and move to help clear your head or look for something positive in a difficult situation. I encourage you to complete at least 2 of these actions for happiness.

“It's not whether you get knocked down, it's whether you get up."

-Vince Lombardi