Laboratories

Consortium of Musculoskeletal Researchers

A multidisciplinary consortium of faculty reside within a large contiguous research facility with extensive shared core resources. In this collaborative environment, faculty, staff, and trainees engage in research programs that are focused on improving the treatment and prevention of musculoskeletal diseases.

Adam Abraham, Ph.D.

Dr. Abraham's research is focused on how musculoskeletal joint structure and function are regulated by inflammatory signaling. I leverage patient-derived tissues, surgical and genetic animal models of human disease, molecular biology, and multi-scale mechanics for applications in exercise adaptation, tendinopathy, osteoarthritis, and intervertebral disc disease.

Killian-Abraham Lab


North Campus Research Complex, Bldg 20, Rm 2828  2800 Plymouth RoadAnn Arbor, MI 48109-2800Phone: 734-647-1528Fax: 734-647-0003

email: adaabrah@med.umich.edu

Published articles via Pubmed 

Andrea Alford, Ph.D.

Dr. Alford's research program focuses on the ECM protein, thrombospondin-2, which promotes commitment of progenitor cells to the osteoblast lineage, facilitates assembly of bone ECM and contributes to skeletal development and regeneration.

Andrea Alford's Lab


A. Alfred Taubman Biomedical Science Research Building, Room 2009  109 Zina Pitcher PlaceAnn Arbor, MI 48109-2200Phone: 734-615-6104Fax: 734-647-0003

email: aialford@med.umich.edu

Published articles via Pubmed 

Rhima Coleman, Ph.D.

Dr. Coleman's research program employs systems level analysis of stem cell chondrogenesis, apply the results of these models to engineer synthetic gene circuits to stabilize stem cell/chondrocyte matrix assembly to engineer functional cartilage tissues, and employ finite element methods to explore strategies to restore joint mechanics to physiologic levels.

Rhima Coleman's Lab


A. Alfred Taubman Biomedical Science Research Building, Room 2019  109 Zina Pitcher PlaceAnn Arbor, MI 48109-2200Phone: 734-764-2694Fax: 734-647-0003

email: rhimacol@med.umich.edu

Published articles via Pubmed 

Kurt Hankenson, D.V.M., Ph.D.

The guiding mission of Dr. Hankenson’s research is to elucidate cellular and molecular mechanisms regulating osteoblastogenesis and bone regeneration.

Kurt Hankenson's Lab


A. Alfred Taubman Biomedical Science Research Building, Room 2021 109 Zina Pitcher PlaceAnn Arbor, MI 48109-2200Phone: 734-936-1713Fax: 734-647-0003

email: kdhank@med.umich.edu

Published articles via Pubmed 

Karl Jepsen, Ph.D., Associate Chair of Research

Dr. Jepsen's laboratory is focused on identifying new ways to diagnose and treat individuals that are at risk of a future fragility fracture.

Karl Jepsen's Lab


North Campus Research Complex, Bldg 25, Rm 2602  2800 Plymouth RoadAnn Arbor, MI 48109-2800Phone: 734-763-2648Fax: 734-647-0003

email: kjepsen@med.umich.edu

Published articles via Pubmed 

Megan Killian, Ph.D.

Dr. Killians's research focus is on identifying key regulators of musculoskeletal growth that can be leveraged to improve musculoskeletal growth and healing. We study the cell and tissue-scale mechanisms underlying pediatric and young adult orthopedic disorders using micro-computed tomography, histology, molecular and cell biology, transgenic mouse models, and mechanical testing.

Killian-Abraham Lab


North Campus Research Complex, Bldg 20, Rm 2826  2800 Plymouth RoadAnn Arbor, MI 48109-2800Phone: 734-936-2566Fax: 734-647-0003

email: mlkillia@med.umich.edu

Published articles via Pubmed 

Kenneth Kozloff, Ph.D.

Dr. Kozloff's research interests revolve around musculoskeletal health, bone injury, and repair.  The laboratory uses translatable models ranging from exercise and adaptation to rare disorders such as osteogenesis imperfecta with a goal to better understand genetic, hormonal, mechanical, and pharmacologic regulators of bone mass and fragility.

Ken Kozloff's Lab


A. Alfred Taubman Biomedical Science Research Building, Room 2015 109 Zina Pitcher PlaceAnn Arbor, MI 48109-2200Phone: 734-936-2158Fax: 734-647-0003

email: kenkoz@umich.edu

Published articles via Pubmed 

Tristan Maerz, Ph.D.

Dr. Maerz’s laboratory is interested in understanding the cellular and molecular mechanisms involved in the pathogenesis of post-traumatic osteoarthritis. By utilizing a variety of translational models and implementing expertise from biomechanics, quantitative imaging, molecular biology, and molecular genetics, Dr. Maerz aims to identify novel avenues for therapeutic intervention after joint injury.

Tristan Maerz's Lab


A. Alfred Taubman Biomedical Science Research Building, Room 2017  109 Zina Pitcher PlaceAnn Arbor, MI 48109-2200Phone: 734-936-2566Fax: 734-647-0003

email: tmaerz@med.umich.edu

Published articles via Pubmed 

Ron Zernicke, Ph.D., D.Sc.

Dr Zernicke's research is on the Functional adaptation of bone to physiological stimuli (exercise, disuse, diet, and disease); joint injury and post-traumatic osteoarthritis; biomechanical mechanisms underlying control of normal and pathological movements.

Michigan Performance Research Laboratory


Domino's Farms, Lobby A, 22624 Frank Lloyd Wright DriveAnn Arbor, MI 48106Phone: 734-232-9586Fax: 734-930-7416

email: zernicke@umich.edu

Published articles via Pubmed 

Steven Goldstein, Ph.D.

Dr. Goldstein's (who founded the ORL in the 1980's and is now Professor Emeritus at the University of Michigan) research has focused on the study of mechanical and biologic regulators of bone formation, regeneration, and adaptation. This work has ranged from studies on embryological bone formation to investigating the consequences of aging on bone integrity and responsiveness. Along with colleagues from multiple disciplines, this research has developed methods of delivering genes to wound sites, promoting "in situ tissue engineering" to treat bone defects, skin ulcers, and ischemic heart disease. Other studies have lead to the development of numerous devices to treat orthopaedic conditions, including surgical instruments and artificial joint components. 

More information on Dr. Goldstein's research can be found here


A. Alfred Taubman Biomedical Science Research Building, Room 2013  109 Zina Pitcher PlaceAnn Arbor, MI 48109-2200Phone: 734-936-7417Fax: 734-647-0003

email: stevegld@med.umich.edu

Published articles via Pubmed