Orthopaedic Research Newsletter

December 2023

Welcome

Happy Holidays From Orthopeadic Research.mp4

Thank you for your hard work and dedication throughout this year. We are so grateful for your efforts and for having each of you as part of our team. We wish you and your loved ones a very happy holiday season and hope you have a safe and relaxing time spent with those nearest and dearest to you.

HAPPY HOLIDAYS!

ASBMR Conference

ASBMR 2023 Annual Meeting

The American Society for Bone and Mineral Research

This year's ASBMR annual meeting was held at the Vancouver Convention Centre on October 13, 2023, in Vancouver, BC, Canada. The ASMBR annual meeting is the world's largest and most diverse meeting focused on bone and mineral metabolism, attracting more than 2,000 attendees from more than 60 countries. This year's topic for the 2023 ASBMR Pre-meeting Symposium on Osteocytes in Bone Health and Disease and as Therapeutic Target Cells, reviewed advances in basic, translational and clinical research on the role of osteocytes in biology and pathophysiology of bone and how to target osteocytes with therapeutics. The annual meeting hosted nearly 100 speaker sessions and 1,000 poster presentations. Our department presented 20 poster presentations and gave 3 oral research presentations. Save the date for next year's ASMBR 2024 annual meeting on September 27, 2024 to be held in Toronto ON Canada!

Congratulations!

Congratulations Conor Locke!

ROBERT A. WINFIELD MHEALTHY CHAMPION AWARD

Conor Locke was recognized as the Second Runner-Up for the 2023 Robert A. Winfield MHealthy Champion Award at the annual MHealthy Champion Retreat. Congratulations to Conor on the significant recognition of his great work!

Conor's Recognition.MP4

Research Highlight

Adam Abraham, PhD

Research Investigator, Orthopaedic Surgery

Dr. Adam Abraham has been with the department since March 2020. His research has helped define the mechanical and structural properties of biological interfaces, examined mechanisms of metabolic dysfunction that disrupt musculoskeletal tissue function, and identified cellular targets to improve treatment of joint pathology. His research interests and active projects are below.

Research Interest:

Dr. Abraham's research interests are in soft-tissue pathologies, with a particular focus right now on tendinopathies. He is also interested in genetic determinants of tendon adaptation due to exercise throughout the lifespan. He has previously studied meniscus and intervertebral disc degeneration.

Active Research Projects:

Studying how the extracellular matrix drives cellular metabolism in tendon health and disease. I collaborate with Megan Killian, Paul Talusan, Claudia Loebel (Materials Science), and Matthew O’Meara (Computational Biology) on this project.
Developing a tendon-specific microphysiological system for studying mechanobiological mechanisms of degeneration as well as a potential platform for drug discovery. We just received notice that this work will be funded by an NIH Katz R01. I collaborate with Claudia Loebel and Brendon Baker (Biomedical Engineering) on this project.
Determining novel genetic mechanisms of tendon development and adaptation using inbred and diversity outbred mouse strains. I collaborate with Nicole Migotsky (our new lab manager) and Matthew Silva (Orthopedic Surgery, Washington University in St. Louis) on this project.
Defining mechanisms of tendon degeneration in Lupus using a mouse model. This is in collaboration with Michelle Kahlenberg (Rheumatology)

Jaimo Ahn, MD, PhD, Professor

Fellow of the ACS, AAOS, AOA

Harold W. and Helen L. Gehring Research Professor of Orthopaedic Surgery

Associate Chair for Education, Orthopaedic Surgery

Chief and Service Co-Director, Orthopaedic Trauma

Dr. Jaimo Ahn has been with the department since 2020. His research interests have been variegated and guided by a philosophy of curious inquiry, team building, learning more about what is little known but also pushing the boundaries. Some would say his journey lacks focus; it would be true. But that lack of focus has allowed him to be a mechanistic bench scientist, a clinical trialist, a start-up consultant, a NIH study section chair, a journal chief editor, and a mentor to learners from high school to tenured professors. Dr. Ahn's current interests range from a U01-supported clinical trial to study the mortality benefits of early surgery for hip fracture patients with demand cardiac ischemia, mechanistic investigations into the role of Activin A and special cell populations in fracture healing, understanding progenitor behaviors in human fracture patients, consortia based guideline development for use of AI in medicine, musculoskeletal care disparities in gender diverse patient populations, psychomotor effects of stress on clinical performance and systematic quantification of soft tissue status in fracture patients...and many more. He always welcomes discussion with colleagues, novices, and experts.

Welcome New Orthopaedic Research Member!

Matt Walker, MAT, AT, ATC

Clinical Research Coordinator

Matt Walker is the new Clinical Research Coordinator at MedSport. Prior to this role, he served as an athletic trainer within collegiate athletics for the past 10 years. He is very thankful for the opportunity to come to Michigan and looks forward to learning and getting to know everyone. He appreciates everyone who has met him already and has been so kind and helpful in his first week here! Go Blue!

Orthopaedic Research Holiday Celebrations

The orthopaedic research community gathered with laughs and cheer on December 12 in BSRB, followed by a staff's waffle breakfast on December 15.

Click here for the recipes: Holiday Recipes

Italian Role

Brined and Roasted Turkey

Grandma's Apple Kuchen

Fudgy Peppermint Brownies

Baby Announcement!

Congratulations to Parents

Tristian and Basma Maerz!

Welcome Baby: Felix Maerz

Born: 10/6/2023

Congratulations to Grandparents

Carol and Dave Whitinger!

Welcome Baby: Ezra Francis Whitinger

Born: 10/30/2023

Recent Publications

Abdel, M.P., C.N. Carender, and D.J. Berry. “Current Practice Trends in Primary Hip and Knee Arthroplasties Among Members of the American Association of Hip and Knee Surgeons.” Journal of Arthroplasty 38, no. 10 (October 1, 2023): 1921-1927.e3. PMID: 37557970 DOI: 10.1016/j.arth.2023.08.005
Dawkins, B., E. Windsor, F. Elali, and W.R. Aibinder. “The Yield of Subsequent Radiographs During Nonoperative Treatment of Radial Head and Neck Fractures.” Scottsdale, Arizona, n.d. Accessed October 1, 2023.
Schaffer, N.E., M. Singh, M.A. McHugh, A.M. Perdue, J. Ahn, A.I. Alford, R. Davenport, et al. “Comparison of True Blood Loss between Short and Long Cephalomedullary Nail Fixation of Geriatric Hip Fractures, a Retrospective Cohort Study.” European Journal of Orthopaedic Surgery and Traumatology 33, no. 7 (October 1, 2023): 2903–9. PMID: 36906665 DOI: 10.1007/s00590-023-03509-x
Powell, D., D. Markel, H. Chubb, S. Muscatelli, R. Hughes, B. Hallstrom, and N. Frisch. “The Differential Effect of COVID on Total Joint Arthroplasty Between Hospital and Ambulatory Surgery Centers/Hospital Outpatient Departments: A Michigan Arthroplasty Registry Collaborative Quality Initiative Analysis.” Arthroplasty Today 23 (October 1, 2023). PMID: 37731594 PMCID: PMC10507191 DOI: 10.1016/j.artd.2023.101189
Johnson, A.K., K.M. Rodriguez, A.S. Lepley, and R.M. Palmieri-Smith. “Quadriceps Torque Complexity before and after Anterior Cruciate Ligament Reconstruction.” Journal of Science and Medicine in Sport 26, no. 10 (October 1, 2023): 533–38. PMID: 37775409 DOI: 10.1016/j.jsams.2023.09.009
Muralidharan, A., J.L. Wilson, J.D. Piche, R.E. Arhewoh, M. Hake, A. Perdue, R. Patel, I. Aleem, and J. Ahn. “Operative Technique for Sacral Insufficiency Fractures Causing Spinopelvic Dissociation: A Case Report.” JBJS Case Connector 13, no. 4 (October 1, 2023). PMID: 37917873 DOI: 10.2106/JBJS.CC.23.00350
Riederer, M. “Pediatric Sports Medicine/Orthopaedic Pearls,” October 4, 2023.
Knights, A.J., E.C. Farrell, O.M. Ellis, M.J. Song, C.T. Appleton, and T. Maerz. “Synovial Macrophage Diversity and Activation of M-CSF Signaling in Post-Traumatic Osteoarthritis.” bioRxiv, October 5, 2023. PMID: 37873464 PMCID: PMC10592932 DOI: 10.1101/2023.10.03.559514
Patel, R. “Complications from Lateral Interbody Fusions,” October 5, 2023.
Z. Xu, C.S. Locke, R. Morris, D. Jamison, K. Kozloff, X. Wang. “Development of a semi-anthropomorphic photoacoustic calcaneus phantom based on nano computed tomography and stereolithography 3D printing.” October 7, 2023. PMID: 37804209 DOI: 10.1002/jor.25702
K. C. Walley, N. Farrar, A. Muralidharan, D.A. Monovoukas, J. Eichman, M. Klueh, A. N. Baumann, A. M. Perdue, M.E. Hake, J. Ahn. “The rate of disuse osteopenia in admitted, non-weight-bearing patients.” October 7, 2023. PMID: 37804218 DOI: 10.1002/jor.25713
Batley, M.G., A.L. Gornitzky, S. Sarkar, and W.N. Sankar. “What Are the Psychosocial Effects of Pavlik Harness Treatment? A Prospective Study on Perceived Impact on Families and Maternal-Infant Bonding.” J Pediatr Orthop, October 9, 2023. PMID: 37807604 DOI: 10.1097/BPO.0000000000002542
Kozloff, Ph.D., K.M. “Bone Stress Injuries, Wearable Technology, and the Quantifiable You,” October 10, 2023.
Trang, K., M.C. Pahl, J.A. Pippin, A. Chesi, Y. Wagley, B.S. Zemel, K.D. Hankenson, A.D. Wells, and S.F.A. Grant. “3D Genomic Features across >50 Diverse Cell Types Reveal Insights into the Differing Genomic Architectures of BMD Determination and Osteoporotic Fracture Pathogenesis.” Vancouver, British Columbia, n.d. Accessed October 12, 2023.
Alford, A., M. Bowman, S. Chen, and A. Reddy. “Thrombospondin Status Affects Gene Expression in MSC-Osteoblasts from Adult Mice.” Vancouver, CA, n.d. Accessed October 12, 2023.
Wagley, Y., T. Maerz, J.A. Pippin, M.C. Pahl, A. Chesi, A.D. Wells, S.F.A. Grant, and K.D. Hankenson. “EPDR1 Governs Metabolic and Immunologic Re-Programming of Human Mesenchymal Stem Cells During Osteoblast Differentiation.” Vancouver, British Columbia, n.d. Accessed October 13, 2023.
Conery, M., J.A. Pippin, Y. Wagley, A.D. Wells, B.F. Voight, B.S. Zemel, K.D. Hankenson, A. Chesi, and S.F.A. Grant. “A Pooled Single-Cell CRISPRi Screen in hFOB1.19 Cells Identifies Effector Genes at BMD GWAS Loci.” Vancouver, British Columbia, n.d. Accessed October 13, 2023.
Wagley, Y., P.K. Acevedo, K. Kessell, R. Goulet, T. Maerz, Ph.D. Kozloff K.M., J.A. Pippin, A. Chesi, S.F.A. Grant, and K.D. Hankenson. “Novel Human Osteoblast Effector Gene EPDR1 Demonstrates Differing Outcomes after Knock-down or Knock-out in Murine In Vitro Osteoblastogenesis and During Murine Bone Modeling.” Vancouver, British Columbia, n.d. Accessed October 13, 2023.
Wagley, Y., B. Graham, and K.D. Hankenson. “C-Jun N-Terminal Kinase (JNK) Isoform 2 Augments Human Osteoblast Differentiation by Integrating Bone Morphogenetic Protein Signaling and Canonical Notch Signaling.” Vancouver, British Columbia, n.d. Accessed October 13, 2023.
Silvestre, J., J. Ahn, S. Mehta, and M.B. Harris. “Impact of the SARS-CoV-2 Outbreak on ACGME-Accredited Orthopaedic Trauma Fellowship Training.” Injury, October 16, 2023, 111137. https://doi.org/10.1016/j.injury.2023.111137.
Weinstein, M.A., A. Beaumont, P. Campbell, H. Hassanzadeh, V. Patel, A. Vokshoor, J. Wind, K. Radcliff, I. Aleem, and D. Coric. “Pulsed Electromagnetic Field Stimulation in Lumbar Spine Fusion for Patients With Risk Factors for Pseudarthrosis.” Int J Spine Surg, October 26, 2023. PMID: 37884337 DOI: 10.14444/8549
R. D. Freshman, A. L. Zhang, C. B. Ma, B. T. Feeley, S. Ortiz, J. Patel, W. Dunn, B. R. Wolf, C. Hettrich, D. Lansdown, K. M Baumgarten, J. Y. Bishop, M. J. Bollier, R. H. Brophy, J. T. Bravman, C. L. Cox, G. L. Cvetanovich, J. A. Grant, R. M. Frank, G. L. Jones, J. E. Kuhn, S. D. Mair, R. G. Marx, E. C. McCarty, B. S. Miller, A. J. Seidl, M. V. Smith, R. W. Wright. “Factors Associated With Humeral Avulsion of Glenohumeral Ligament Lesions in Patients With Anterior Shoulder Instability: An Analysis of the MOON Shoulder Instability Cohort. “ October 27, 2023. PMID: 37900861 PMCID: PMC10612462 DOI: 10.1177/23259671231206757
Aibinder, W.R. “Get Me Back in the Game: A Case-Based Roundtable Discussion on Athletic Shoulder Injuries,” October 2023.
Abdel, M.P., C.N. Carender, N.A. Bedard, K.I. Perry, M.W. Pagnano, and A.D. Hanssen. “Marlex Mesh Reconstruction of the Extensor Mechanism: Mid-Term Follow-up of 93 Total Knee Arthroplasties.” Dallas, Texas, n.d. Accessed November 1, 2023.
Gedailovich, S., A. Monas, R. Schrier, and W.R. Aibinder. “Do Outcomes of Interposition Arthroplasty in Young Patients Differ Based on Indication? A Systematic Review.” Journal of Shoulder and Elbow Surgery 32, no. 11 (November 1, 2023): 2412–20. PMID: 37423462 DOI: 10.1016/j.jse.2023.05.042
Carender, C.N., C.E. Bothun, R.J. Sierra, R.T. Trousdale, M.P. Abdel, and N.A. Bedard. “Aseptic Revision Total Hip Arthroplasty in Patients 50 Years and Younger: Results of Over 500 Cases.” Dallas, Texas, n.d. Accessed November 1, 2023.
Carender, C.N., C.E. Bothun, M.J. Taunton, K.I. Perry, N.A. Bedard, and M.W. Pagnano. “American Association of Hip and Knee Surgeons Annual Meeting.” Dallas, Texas, n.d. Accessed November 1, 2023.
Carender, C.N., K.M. Fruth, D.G. Lewallen, D.J. Berry, M.P. Abdel, and N.A. Bedard. “Obesity and TKA: The Absolute vs. Relative Risk of PJI at 15 Years.” Dallas, Texas, n.d. Accessed November 1, 2023.
Carender, C.N., D.R. Larson, R.T. Trousdale, D.G. Lewallen, D.J. Berry, and M.P. Abdel. “Aseptic Revision THA Using Modular Fluted Tapered Stems: Long-Term Update of 515 Cases.” Dallas, Texas, n.d. Accessed November 1, 2023.
Carender, C.N., M.J. Taunton, K.M. Fruth, M.W. Pagnano, and M.P. Abdel. “Modular Dual-Mobility Constructs Outperformed Large Femoral Heads in 299 Revision THAs at 10 Years.” Dallas, Texas, n.d. Accessed November 1, 2023.
Rosario, R., E.M. Arruda, J.A. Grant, and R.M. Coleman. “Cartilage Thickness Mismatches in Patellar Osteochondral Allograft Transplants Affect Local Cartilage Stresses.” Journal of Orthopaedic Research 41, no. 11 (November 1, 2023): 2372–83. PMID: 37031360 PMCID: PMC10560315 (available on 2024-11-01) DOI: 10.1002/jor.25569
Van Engen, M.G., C.N. Carender, N.A. Glass, and N.O. Noiseux. “Functional Outcomes after Successful DAIR for Acute Periprosthetic Joint Infection of TKA.” Dallas, Texas, n.d. Accessed November 1, 2023.
Pajares-Chamorro, N., S. Hernández-Escobar, Y. Wagley, P. Acevedo, M. Cramer, S. Badylak, N.D. Hammer, J. Hardy, K. Hankenson, and X. Chatzistavrou. “Silver-Releasing Bioactive Glass Nanoparticles for Infected Tissue Regeneration.” Biomaterials Advances 154 (November 1, 2023). PMID: 37844416 DOI: 10.1016/j.bioadv.2023.213656
S. Hasan, I. Aleem, D. Park, D. Nerenz, M. Abdulhak, M. Perez-Cruz, J. Schwalb, E. S. Saleh, R.Easton, J. G. Khalil. “The Duration of Symptoms Influences Outcomes After Lumbar Microdiscectomies: A Michigan Spine Surgery Improvement Collaborative.” November 2, 2023. https://doi.org/10.1177/21925682231210469
Locke, C.S., T. Waanders, D. Thornberg, A. Booth, R. Goulet, K. Jepsen, B. Ramo, and G.Y. Li. “Why Do Some Magnetically Controlled Growing Rods (MCGR) Lengthen While Others Stall? A Clinical and Nano-CT Cross-Tabulation Analysis of MCGR Explants.” Charleston, South Carolina, n.d. Accessed November 8, 2023.
Shams, K., S. Jha, J. Swallow, M.S. Caird, F.A. Farley, M. Stepanovich, and G.Y. Li. “Serum Titanium Levels Remain Elevated but Urine Titanium Is Undetectable in Children with Early Onset Scoliosis (EOS) Undergoing Growth-Friendly Surgical Treatment: A Prospective Study.” Charleston, South Carolina, n.d. Accessed November 8, 2023.
Shams, K., S. Jha, J. Swallow, M.S. Caird, F.A. Farley, M. Stepanovich, and Y. Li. “Serum Titanium Levels Remain Elevated But Urine Titanium Is Undetectable in Children With Early Onset Scoliosis Undergoing Growth-Friendly Surgical Treatment: A Prospective Study.” J Pediatr Orthop, November 13, 2023. PMID: 37953656 DOI: 10.1097/BPO.0000000000002565
Jacobson, A.R., J. Blaszczak, J. Ahn, and B.L. Viglianti. “DEXA Screening for Transgender and Gender Diverse Patients: An Overview of Current Guidance and Call for Improved Protocols.” Acad Radiol, November 15, 2023. PMID: 37977892 DOI: 10.1016/j.acra.2023.10.037
Okike, K., H.A. Prentice, P.H. Chan, B.H. Fasig, E.W. Paxton, J. Bernstein, J. Ahn, and F. Chen. “Unipolar Hemiarthroplasty, Bipolar Hemiarthroplasty, or Total Hip Arthroplasty for Hip Fracture in Older Individuals.” J Bone Joint Surg Am, November 16, 2023. PMID: 37973035 DOI: 10.2106/JBJS.23.00486
Aibinder, W.R. “Coronoid Fractures,” December 2023.
Putera, K.H., J. Kim, S.Y. Baek, S.H. Schlecht, M.L. Beaulieu, V. Haritos, E.M. Arruda, J.A. Ashton-Miller, E.M. Wojtys, and M.M. Banaszak Holl. “Fatigue-Driven Compliance Increase and Collagen Unravelling in Mechanically Tested Anterior Cruciate Ligament.” Communications Biology 6, no. 1 (December 1, 2023). https://doi.org/10.1038/s42003-023-04948-2.
Reed, L.A., K.A. Hao, D.A. Patch, J.J. King, C. Fedorka, J. Ahn, J.A. Strelzow, et al. “How Do Surgeons Decide When to Treat Proximal Humerus Fractures with Operative versus Nonoperative Management?” European Journal of Orthopaedic Surgery and Traumatology 33, no. 8 (December 1, 2023): 3683–91. https://doi.org/10.1007/s00590-023-03610-1.

Upcoming Funding Opportunities and Deadlines

NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed): PA-20-185
NIH Research Project Grant (Parent R01 Basic Experimental Studies with Humans Required): PA-20-184
NIH Research Project Grant (Parent R01 Clinical Trial Required): PA-20-183
NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Not Allowed): PA-20-195
NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Required): PA-20-194
NIH Exploratory/Developmental Research Grant Program (Parent R21 Basic Experimental Studies with Humans Required): PA-20-196

Do Good December

This month's theme is "Do Good December" which is especially meaningful during this time of year. I challenge you to do good this December. One could give something away that you no longer need, donate to a local food bank, volunteer in your local community, or simply call a distant relative to say hello and have a chat. I encourage you to do good by completing at least 2 of these actions this December.

“Kindness is doing what you can, where you are, with what you have”. -Raktivist.